Trifunctional Graphene Quantum Dot@LDH Integrated Nanoprobes for Visualization Therapy of Gastric Cancer

Visualization technology has become a trend in tumor therapy recent years. The superior optical properties of graphene quantum dots (GQDs) make them suitable candidates for diagnosis, but their targeting and drug-carrying capacities are still not ideal treatment. Sulfur-doped (SGQDs) with stable fluorescence prepared previous study. A reliable strategy by associating layered double hydroxides (LDHs) etoposide (VP16) is designed precise visualization therapy. Trifunctional LDH@SGQD-VP16 integrated nanoprobes can simultaneously achieve targeted aggregation, visualization, chemotherapy. accumulate the microenvironment, owing to pH-sensitive long-term photostability vivo, which provide basis cancer targeting, real-time imaging, effect tracking. enhanced therapeutic attenuated side effects VP16 demonstrated, apoptosis caused ≈2.7 times higher than that alone, HGC-27 cells. This work provides theoretical experimental as potential multifunctional agent gastric cancer.